Saxagliptin Impurity 24 CAS 841302-24-7(free base)
| CAS No. | 841302-24-7(free base) |
| Molecular Formula | C18H25N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Saxagliptin Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Saxagliptin Impurity 24 (CAS 841302-24-7(free base), C18H25N3O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Saxagliptin Impurity 24 (C18H25N3O3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H25N3O3 HCl |
| Molecular Weight | 367.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Saxagliptin Standards
- Saxagliptin Impurity N1 (CAS 102502-64-7)
- Saxagliptin Hydrochloride Dihydrate (CAS 1073057-20-1)
- Saxagliptin Impurity N52 (CAS 1194836-75-3)
- Saxagliptin Cyclic Imidine Impurity (CAS 1194836-77-5)
- (±)-Saxagliptin-13C3 (acetyl-13C2,cyclopropyl-3-13C) (CAS 1246812-44-1)
- Saxagliptin-15N,D2 Hydrochloride (CAS 1309934-06-2)
- Saxagliptin Impurity 60 Mesylate (CAS 1312338-82-1)
- Saxagliptin Impurity 6 (CAS 1334321-39-9)
Recommended Standards
- Empagliflozin impurity 266 (CAS CATO-C4X-1065266)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Peficitinib Impurity 8 (CAS 944123-25-5)
- (R)-3-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid (CAS 108919-51-3)
- (3-Bromophenyl)(imino)(trifluoromethyl)-l6-sulfanone (CAS 2411289-54-6)
- Cyclophosphamide impurity 41 (CAS CATO-C4X-230641)
- 4-(3-Trifluoromethyl-benzyl)-piperidine (CAS 37581-28-5)
- Ethyl (4-(2-((4-carbamoylphenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate (CAS 953137-00-3)
- 2-Amino-N-(1-benzylpyrrolidin-3-yl)acetamide (CAS 1152838-28-2)
- Tirzepatide Impurity 38 (CAS CATO-C4X-324038)
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